7/7/2023 0 Comments Rj yeatmanWe selected the top 10 TFs as candidate master regulators to show the highest coverage of the signature genes among the total 846 TF-target sub-networks or regulons. To this end, a global transcriptional regulatory network was constructed with total >200,000 TF-target links using the ARACNE algorithm. In order to identify prognostic master regulators, we took the known 85 prognostic signature genes for colorectal cancer and inferred their upstream TFs. Their upstream regulators such as transcription factors (TFs) may take a more critical role as drivers or master regulators to provide better clues on the underlying regulatory mechanisms and therapeutic applications. However, expression signatures frequently include many passengers, which are not directly related to cancer progression. Gene expression signatures have been commonly used as diagnostic and prognostic markers for cancer subtyping.
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